| 关节面不平整程度对骨软骨愈合的影响 |
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投稿时间：2010-12-28
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| 作者 | Author | 单位 | Address | E-Mail |
| 孙骏 |
SUN Jun |
上海中医药大学附属曙光医院骨科，上海 200021 |
Department of Orthopaedics,Shuguang Hospital,Shanghai Traditional Chinese Medical University,Shanghai 200021,China |
drsunjun@163.com |
| 侯筱魁 |
HOU Xiao-kui |
上海交通大学医学院附属第九人民医院骨科 |
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| 匡勇 |
KUANG Yong |
上海中医药大学附属曙光医院骨科，上海 200021 |
Department of Orthopaedics,Shuguang Hospital,Shanghai Traditional Chinese Medical University,Shanghai 200021,China |
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| 卫晓恩 |
WEI Xiao-en |
上海中医药大学附属曙光医院骨科，上海 200021 |
Department of Orthopaedics,Shuguang Hospital,Shanghai Traditional Chinese Medical University,Shanghai 200021,China |
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| 期刊信息：《中国骨伤》2011年，第24卷，第6期，第505-508页 |
| DOI：10.3969/j.issn.1003-0034.2011.06.020 |
| 基金项目: |
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中文摘要:
目的：探讨关节面不同程度的不平整是否会对骨软骨的修复产生影响。
方法：选取雄性6月龄25 kg崇明山羊8只，对山羊股骨内髁负重区制造骨软骨缺损，并通过骨软骨移植修复，形成0.5、1.0、2.0 mm关节软骨凸出和凹陷。术后12周处死动物，进行大体观察、组织学HE染色以及透射电镜检查。参照 O'Driscoll,Keeley and Salter组织形态学评分标准进行评分。
结果：0.5 mm和1.0 mm的凸出性和凹陷性软骨台阶的大体观察及组织学染色显示关节面恢复平整，透射电镜示修复组织与正常软骨一致。2.0 mm的台阶不能使关节面的平整获得修复，透射电镜示纤维束增生，软骨细胞变性。2.0 mm台阶的组织学评分低于0.5 mm和1.0 mm台阶，差异均有统计学意义。
结论：关节面的不平整对修复会有影响，在一定范围内的台阶样不平整可以自身修复。 |
| 【关键词】软骨，关节 修复外科手术 骨移植 组织学 |
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| Influence of the unevenness of articular surface on the osteochondral repair |
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ABSTRACT
Objective: To investigate whether the unevenness of articular surface would affect the osteochondral repair.
Methods: Eight Shanghai Chongming 6-months-old masculine goats with a mean weight of 25 kg were used in this study. Different unevenness,which were 0.5 mm,1.0 mm,2.0 mm protrude or concavity,were created on the weight-bearing portion of the medial femoral condyles of the goats. The goats were sacrificed 12 weeks later and were observed with the general observation,HE staining and transmission electron microscope. To evaluate the microscopic morphology,a histological grading scale described by O'Driscoll,Keeley and Salter was used.
Results: The general observation and HE staining showed that the unevenness of 0.5 mm or 1.0 mm protrudes or concavity could be repaired to get the surface smooth on the whole. The transmission electron microscope showed that the reparative tissues were the same as the normal cartilage. The 2.0 mm depth couldn't be repaired satisfactorily. The transmission electron microscope showed that the fiber bundle proliferated and the chondrocytes degenerated. The scores of the 2.0 mm depth were significantly lower than that of the 0.5 mm or 1.0 mm(P<0.05).
Conclusion: The unevenness could have an influence on the repair. The limited unevenness could be repaired by itself. |
| KEY WORDS Cartilage,articular Reconstructive surgical procedures Bone transplantation Histology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 孙骏,侯筱魁,匡勇,卫晓恩.关节面不平整程度对骨软骨愈合的影响[J].中国骨伤,2011,24(6):505~508 |
| 英文格式: | SUN Jun,HOU Xiao-kui,KUANG Yong,WEI Xiao-en.Influence of the unevenness of articular surface on the osteochondral repair[J].zhongguo gu shang / China J Orthop Trauma ,2011,24(6):505~508 |
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