| 全髋关节置换术后血清炎性因子表达特点及临床意义 |
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投稿时间：2011-02-20
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| 作者 | Author | 单位 | Address | E-Mail |
| 梅晓亮 |
MEI Xiao-liang |
南京大学医学院临床学院 南京军区南京总医院骨科，江苏 南京 210002 |
Department of Orthopaedics,Nanjing General Hospital of Nanjing Military Command of PLA,Nanjing 210002,Jiangsu,China |
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| 郭亭 |
GUO Ting |
南京大学医学院临床学院 南京军区南京总医院骨科，江苏 南京 210002 |
Department of Orthopaedics,Nanjing General Hospital of Nanjing Military Command of PLA,Nanjing 210002,Jiangsu,China |
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| 赵建宁 |
ZHAO Jian-ning |
南京大学医学院临床学院 南京军区南京总医院骨科，江苏 南京 210002 |
Department of Orthopaedics,Nanjing General Hospital of Nanjing Military Command of PLA,Nanjing 210002,Jiangsu,China |
zhaojianning.0207@163.com |
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| 期刊信息：《中国骨伤》2011年，第24卷，第6期，第463-465页 |
| DOI：10.3969/j.issn.1003-0034.2011.06.006 |
| 基金项目:全军医学科学技术研究“十一五”计划课题(编号：06G043) |
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中文摘要:
目的：研究血清炎性因子白介素-1(IL-1) 、白介素-2(IL-2)、白介素-6 ( IL-6 ) 及白介素-10 ( IL-10 )在人工全髋关节置换术后变化特点及意义。
方法：自2010年2月至6月，选择初次行单侧人工全髋关节置换术的30例股骨头无菌性坏死患者，男18例，女12例；年龄52～70岁，平均(58.4±6.6)岁；FicatⅡ型20例，Ⅲ型10例。分别在术前第1天及术后第1、3天用放射免疫方法检测 IL-1、IL-2、IL-6及IL-10,同时检测C反应蛋白，对结果进行统计学分析。
结果：人工全髋关节置换术后第1天患者血清中IL-1、IL-6和IL-10值均较术前升高(t=2.62,3.51,2.21,P<0.05),在术后1～3 d达到高峰，3 d 后开始降低。患者血清IL-2水平术后降低(t=2.16,P<0.05 ),后逐渐升高。
结论：全髋关节置换术后3 d是抗炎治疗的关键，术后及时监测IL-1、IL-2、IL-6及IL-10的变化，同时观察临床症状，可更敏感地掌握患者的治疗效果，预测病情发展。 |
| 【关键词】关节成形术，置换，髋 炎症趋化因子类 放射免疫测定 股骨头坏死 |
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| Clinical significance and expression of the inflammatory cytokines(IL-1,IL-2,IL-6 and IL-10) in blood serum of the patients after total hip replacement |
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ABSTRACT
Objective: To evaluate the changes in the expressions of the inflammatory cytokines (IL-1,IL-2,IL-6 and IL-10) in blood serum of the patients after total hip replacement(THR).
Methods: From February 2010 to June 2010,thirty patients undergone primary total hip arthroplasty in one side including 18 male and 12 female with the mean age of(58.4±6.6) years (ranged from 52 to 70 years) . Twenty patients were Ficat Ⅱ type,and 10 patients were Ficat Ⅲ type. The contents of IL-1,IL-2,IL-6 and IL-10 in blood serum were detected on the day before operation and 1,3 days after operation respectively by ELISA. At the same time,the content of C reactive protein was also detected,and the results were statistically analyzed.
Results: The contents of IL-1,IL-6 and IL-10 in the serum of patients at the first day after THR were significantly higher than those before operation(t=2.62,3.51,2.21,P<0.05),and reached the peak at 1 to 3 days after operations,then subsequently decreased. However,the content of IL-2 in the serum of patients after operation was obvious lower (t=2.16,P<0.05),and recovered to normal level gradually.
Conclusion: It is the key time of treatment at 1 to 3 days after THR. Monitoring IL-1,IL-2,IL-6 and IL-10 after operation in time,and monitoring life sign at the same time could sensitively observe the effect of treatment and forecast the trend of diseases in patients. |
| KEY WORDS Arthroplasty replacement,hip Chemokines Radioimmunoassay Femur head necrosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 梅晓亮,郭亭,赵建宁.全髋关节置换术后血清炎性因子表达特点及临床意义[J].中国骨伤,2011,24(6):463~465 |
| 英文格式: | MEI Xiao-liang,GUO Ting,ZHAO Jian-ning.Clinical significance and expression of the inflammatory cytokines(IL-1,IL-2,IL-6 and IL-10) in blood serum of the patients after total hip replacement[J].zhongguo gu shang / China J Orthop Trauma ,2011,24(6):463~465 |
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