| 透明质酸钠黏弹性补充治疗膝骨性关节炎的远期疗效观察 |
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投稿时间：2010-04-19
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| 作者 | Author | 单位 | Address | E-Mail |
| 闫立 |
YAN Li |
中国中医科学院望京医院关节二科，北京 100102 |
The 2nd Department of Joint,Wangjing Hospital,China Academy of Chinese Medical Science,Beijing 100102,China |
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| 梁朝 |
LIANG Zhao |
中国中医科学院望京医院关节二科，北京 100102 |
The 2nd Department of Joint,Wangjing Hospital,China Academy of Chinese Medical Science,Beijing 100102,China |
lyliang@163bj.com |
| 温建民 |
WEN Jian-min |
中国中医科学院望京医院关节二科，北京 100102 |
The 2nd Department of Joint,Wangjing Hospital,China Academy of Chinese Medical Science,Beijing 100102,China |
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| 李丁 |
LI Ding |
中国中医科学院西苑医院 |
The 2nd Department of Joint,Wangjing Hospital,China Academy of Chinese Medical Science,Beijing 100102,China |
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| 荀淑英 |
XUN Shu-ying |
中国中医科学院望京医院关节二科，北京 100102 |
The 2nd Department of Joint,Wangjing Hospital,China Academy of Chinese Medical Science,Beijing 100102,China |
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| 李智尧 |
LI Zhi-yao |
中国中医科学院望京医院关节二科，北京 100102 |
The 2nd Department of Joint,Wangjing Hospital,China Academy of Chinese Medical Science,Beijing 100102,China |
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| 期刊信息：《中国骨伤》2010年，第23卷，第7期，第547-550页 |
| DOI：10.3969/j.issn.1003-0034.2010.07.023 |
| 基金项目: |
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中文摘要:
目的：通过回顾性分析关节腔注射透明质酸钠对膝骨性关节炎的远期效果，为黏弹性补充疗法提供临床依据。
方法：2006年1月至2007年8月治疗膝骨性关节炎181膝（120例）,其中轻度61膝，中度72膝，重度48膝。采用透明质酸钠关节腔内注射治疗，每次2 ml,每周1次，连续5周为1个疗程。应用VAS视觉模拟标尺法、日本骨科协会（JOA）的膝关节骨性关节炎评分系统，分别于治疗前及治疗后1个月、1、2年进行疗效评估。
结果：①VAS疼痛分值：治疗前平均（7.26±1.83）分，治疗后1个月平均（1.85±1.21）分，随访1年时平均（2.54±1.40）分，随访2年时平均（3.07±1.51）分，均比治疗前降低。②JOA膝关节功能评分：治疗前平均（18.7±6.6）分，治疗后1个月平均（84.3±15.5）分，1年平均（75.4±22.4）分，2年平均（64.8±25.6）分，均较治疗前提高。③远期疗效评估：采用JOA评分方法，181膝治疗后1个月优91膝，良49膝，可27膝，差14膝；1年后优70膝，良51膝，可31膝，差29膝；2年后优40膝，良50膝，可46膝，差45膝。随着时间推移，疗效逐渐下降。治疗2年时轻度患者优16膝，良22膝，可15膝，差8膝；中度患者优16膝，良20膝，可21膝，差15膝；重度患者优8膝，良8膝，可10膝，差22膝。
结论：关节腔注射透明质酸钠对膝骨性关节炎具有良好的远期疗效，尤其对轻、中度骨性关节炎更为满意，对重度骨性关节炎近期疗效尚可，远期疗效较差。 |
| 【关键词】骨关节炎，膝 透明质酸 注射，关节内 |
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| Observation of long-term efficacy of visco-supplementation with sodium hyaluronate in treating knee osteoarthritis |
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ABSTRACT
Objective: To retrospectively analyze the long-term efficacy of intra-articular injection with sodium hyaluronate for the treatment of knee osteoarthritis.
Methods: From January 2006 to August 2007,120 patients(181 knees) with knee osteoarthritis,(mild 61 knees,moderate 72 knees,severe 48 knees),were treated by intra-articular injection with sodium hyaluronate,2 ml every week for 5 weeks. The clinical effects were analyzed according to VAS,JOA scoring before treatment,at the 1 month,1,2 years after treatment.
Results: ①VAS scores were respectively(7.26±1.83),(1.85±1.21),(2.54±1.40),(3.07±1.51) scores before treatment,at the 1 month,1 and 2 years after treatment. There was significant difference between every post-treatment and pre-treatment. ②JOA scoring of knee function was respectively(18.7±6.6),(84.3±15.5),(75.4±22.4),(64.8±25.6) scores before treatment,at the 1 month,1 and 2 years after treatment. There was significant difference between every post-treatment and pre-treatment. ③Assessment of long-term efficacy among 181 knees who were followed up 1 year ,70 cases got excellent results,54 good,34 fair and 23 poor. Those who were followed up 2 years,40 cases got excellent results,54 good,53 fair and 34 poor. Knee function became poor along with time-lapse. The efficiency was respectively 86.89%(53/61),79.17%(57/72),54.17%(26/48) in mild knees,moderate knees,severe knees at the 2 years after treatment.
Conclusion: The long-term efficacy of intra-articular injection with sodium hyaluronate is satisfactory in treating knee osteoarthritis. The efficacy is better for mild and moderate osteoarthritis than for the severe osteoarthritis. The short-term efficacy is acceptable and the long-term one is worse for the severe knees. |
| KEY WORDS Osteoarthritis,knee Hyaluronic acid Injections,intra-articular |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 闫立,梁朝,温建民,李丁,荀淑英,李智尧.透明质酸钠黏弹性补充治疗膝骨性关节炎的远期疗效观察[J].中国骨伤,2010,23(7):547~550 |
| 英文格式: | YAN Li,LIANG Zhao,WEN Jian-min,LI Ding,XUN Shu-ying,LI Zhi-yao.Observation of long-term efficacy of visco-supplementation with sodium hyaluronate in treating knee osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2010,23(7):547~550 |
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