| 激素性股骨头坏死遗传易感性的研究进展 |
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| 期刊信息：《中国骨伤》2010年，第23卷，第2期，第156-159页 |
| DOI：10.3969/j.issn.1003-0034.2010.02.029 |
| 基金项目:1.国家自然科学基金(编号：30672700);2.山东省博士后创新项目专项基金(编号：200803013) |
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| 中文摘要:激素性股骨头坏死的发病机制目前尚未明确，近年来的研究表明激素性股骨头坏死患者的发病与遗传易感因素有关。本文就激素代谢、转运、抵抗和激素受体基因以及血液凝溶系统、脂肪代谢、骨代谢的相关基因多态性与股骨头坏死对激素敏感性的关联研究概况予以综述，讨论了研究的有关问题及对策，并就研究前景进行了展望。 |
| 【关键词】股骨头坏死 糖皮质激素 遗传易感性 基因多态性 |
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| Advances in researches on genetic predisposition to steroid-induced osteonecrosis of the femoral head |
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| ABSTRACT The pathogenesis of steroid-induced osteonecrosis of the femoral head(SONFH) is not very clear at present. For the past few years researches showed that the SONFH related to genetic predisposing factors. The related research progresses were reviewed in this article to show the correlation between genetic mutation and genetic polymorphism of steroid metabolism and transport,resistance and receptor,coagulation and fibrinolysis,lipid and bone metabolism and susceptibility to SONFH. The article also discussed current problems,countermeasure and future applications. |
| KEY WORDS Femur head necrosis Glucocorticoid Genetic susceptibility Gene polymorphism |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 曾平,韦标方,何伟,苏式兵.激素性股骨头坏死遗传易感性的研究进展[J].中国骨伤,2010,23(2):156~159 |
| 英文格式: | ZENG Ping,WEI Biao-fang,HE Wei,SU Shi-bing.Advances in researches on genetic predisposition to steroid-induced osteonecrosis of the femoral head[J].zhongguo gu shang / China J Orthop Trauma ,2010,23(2):156~159 |
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