| 血管内皮生长因子在强直性脊柱炎活动期病理性表达的临床对照试验 |
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投稿时间：2007-10-10
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| 作者 | Author | 单位 | Address | E-Mail |
| 钱奕铭 |
QIAN Yi-ming |
第三军医大学新桥医院骨科，重庆 400037 |
Department of Orthopaedics,the Xinqiao Hospital of the Third Military Medical University,Chongqing 400037,China |
qym2006119@hotmail.com |
| 初同伟 |
CHU Tong-wei |
第三军医大学新桥医院骨科，重庆 400037 |
Department of Orthopaedics,the Xinqiao Hospital of the Third Military Medical University,Chongqing 400037,China |
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| 李建明 |
LI Jian-ming |
第三军医大学新桥医院骨科，重庆 400037 |
Department of Orthopaedics,the Xinqiao Hospital of the Third Military Medical University,Chongqing 400037,China |
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| 刘玉刚 |
LIU Yu-gang |
第三军医大学新桥医院骨科，重庆 400037 |
Department of Orthopaedics,the Xinqiao Hospital of the Third Military Medical University,Chongqing 400037,China |
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| 期刊信息：《中国骨伤》2008年，第21卷，第9期，第649-651页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)在强直性脊柱炎(ankylosing spondylitis,AS)活动期骶髂关节滑膜的病理性表达及意义。
方法：通过原位杂交技术检测活动期AS患者与对照组(骨盆骨折患者)骶髂关节滑膜组织中VEGF的表达，用图像分析系统比较它们的表达差异。
结果：在活动期AS患者骶髂关节滑膜组织中VEGF阳性表达，而对照组骶髂关节滑膜组织中VEGF阴性表达，阳性细胞计数及平均灰度值比较差异有统计学意义(P﹤0.01).
结论：VEGF为强直性脊柱炎发病机制中的重要因子，与强直性脊柱炎骶髂关节骨与软骨的破坏及成骨硬化过程密切相关，控制VEGF的表达可能阻断AS的骨质破坏及病理性成骨硬化，为治疗强直性脊柱炎提供新的思路。 |
| 【关键词】脊柱炎，强直性 血管内皮生长因子类 骶髂关节 原位杂交 临床对照试验 |
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| Controlled clinical trials on the pathological expressions of VEGF in patients with active ankylosing spondylitis |
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ABSTRACT
Objective: To investigate the pathological expression and significance of VEGF in patients with active ankylosing spondylitis.
Methods: The expression of VEGF in the synovial tissues of cacroiliac joint of patients with active AS was detected by using in situ hybridization and the results were compared with those in the patients with pelvic fracture using image analysis system.
Results: The positive expressions of VEGF in the synovial tissues of cacroiliac joint of patients with active AS were stronger than those in the control group(P<0.01).
Conclusion: VEGF are important factors in patients with active AS. They are tightly correlated with the process of osteoclasia and pathological new bone formation in the cacroiliac joint of patients with active AS. If we can reduce the expressions of VEGF in the patients with active AS,the process of osteoclasia and pathological new bone formation will be interrupted and this provides a new strategy for the treatment of ankylosing spondylitis. |
| KEY WORDS Spondylitis,ankylosing Vascular endothelial growth factors Sacroiliac joint In situ hybridization Controlled clinical trials |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 钱奕铭,初同伟,李建明,刘玉刚.血管内皮生长因子在强直性脊柱炎活动期病理性表达的临床对照试验[J].中国骨伤,2008,21(9):649~651 |
| 英文格式: | QIAN Yi-ming,CHU Tong-wei,LI Jian-ming,LIU Yu-gang.Controlled clinical trials on the pathological expressions of VEGF in patients with active ankylosing spondylitis[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(9):649~651 |
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