| 鹿瓜多肽治疗类风湿关节炎临床疗效观察 |
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投稿时间：2008-07-03
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| 作者 | Author | 单位 | Address | E-Mail |
| 郭生玉 |
GUO Sheng-yu |
中国医科大学附属盛京医院风湿免疫科，辽宁 沈阳 110004 |
Department of Rheumatology and Immunology,Shengjing Hospital, China Medical University,Shenyang 110004,Liaoning,China |
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| 林连捷 |
LIN Lian-jie |
中国医科大学附属盛京医院消化内科 |
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| 楚华 |
CHU Hua |
宽甸县中心医院中西医结合科 |
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| 杨川 |
YANG Chuan |
中国医科大学附属盛京医院风湿免疫科，辽宁 沈阳 110004 |
Department of Rheumatology and Immunology,Shengjing Hospital, China Medical University,Shenyang 110004,Liaoning,China |
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| 宫丹丹 |
GONG Dan-dan |
中国医科大学附属盛京医院风湿免疫科，辽宁 沈阳 110004 |
Department of Rheumatology and Immunology,Shengjing Hospital, China Medical University,Shenyang 110004,Liaoning,China |
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| 田佳 |
TIAN Jia |
中国医科大学附属盛京医院风湿免疫科，辽宁 沈阳 110004 |
Department of Rheumatology and Immunology,Shengjing Hospital, China Medical University,Shenyang 110004,Liaoning,China |
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| 付海香 |
FU Hai-xiang |
中国医科大学附属盛京医院风湿免疫科，辽宁 沈阳 110004 |
Department of Rheumatology and Immunology,Shengjing Hospital, China Medical University,Shenyang 110004,Liaoning,China |
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| 期刊信息：《中国骨伤》2008年，第21卷，第8期，第610-612页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：评估鹿瓜多肽注射液对类风湿关节炎(RA)的临床疗效。
方法：选择50例活动期RA患者，分为对照组与治疗组。两组均给予基础治疗：帕夫林(白芍总苷)口服，600 mg,每日2次；妥抒(来氟米特)口服，20 mg/d.同时，治疗组应用松梅乐(鹿瓜多肽注射液)静脉点滴，16 mg/d,连续2周；对照组给予西乐葆(塞来昔布)口服，200 mg,每日2次，连续2周。于治疗前后检测血沉、C-反应蛋白(CRP)、类风湿因子(RF)、肝功、血常规及尿常规，并观察患者关节疼痛、肿胀症状改善情况及化验检查的变化。
结果：治疗组关节肿痛改善情况明显优于对照组及治疗前，血沉、CRP及RF的下降程度明显高于对照组及治疗前。治疗组治疗前后无肝功、血白细胞及尿改变。
结论：鹿瓜多肽注射液治疗RA活动期患者，起效快，短期疗效确切，安全性高，是RA急性期治疗的理想药物。 |
| 【关键词】鹿瓜多肽 关节炎，类风湿 临床对照试验 |
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| Efficacy of Lugua polypeptide injection on active rheumatoid arthritis |
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ABSTRACT
Objective: To investigate the therapeutic effect of Lugua polypeptide on active rheumatoid arthritis (RA).
Methods: Fifty patients with active RA were selected for the study and were randomly divided into study group and control group. Patients in study group were treated with Lugua polypeptide intravenously at a dose of 16 mg per day and those in control group were given Celecoxib 200 mg twice a day for successive 2 weeks. Two groups were given the same basic treatment. Tenderness and swelling of joints,morning stiffness,erythrocyte sedimentation rate,C-reactive protein,rheumatoid factor and so on were recorded before and after treatment.
Results: The above index on joints in study group was significantly improved compared with that in control group and the level before treament. No apparent side effects were observed.
Conclusion: Lugua polypeptide is effective and safe on active RA. It is a promising agent in the treatment of RA. |
| KEY WORDS Lugua polypeptide Arthritis,rheumatoid Controlled clinical trials |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 郭生玉,林连捷,楚华,杨川,宫丹丹,田佳,付海香.鹿瓜多肽治疗类风湿关节炎临床疗效观察[J].中国骨伤,2008,21(8):610~612 |
| 英文格式: | GUO Sheng-yu,LIN Lian-jie,CHU Hua,YANG Chuan,GONG Dan-dan,TIAN Jia,FU Hai-xiang.Efficacy of Lugua polypeptide injection on active rheumatoid arthritis[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(8):610~612 |
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