| 鹿茸多肽对脊髓损伤保护作用的实验研究 |
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投稿时间：2008-01-25
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| 期刊信息：《中国骨伤》2008年，第21卷，第4期，第285-286页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：观察鹿茸多肽应用于脊髓损伤大鼠的治疗效果。
方法：75只雄性Wister大鼠随机分为正常对照组、空白手术组、15 、10 、5 mg治疗组，每组15只。通过脊髓损伤动物模型，各治疗组分别注射15、10、5 mg鹿茸多肽，正常对照组皮下注射生理盐水，空白手术组造模后不予处理，给药7 d.观察其对脊髓损伤动物的动能测定及脊髓病理变化的影响。
结果：15、10、5 mg不同剂量鹿茸多肽给药7 d后，大鼠运动功能有所恢复，明显高于手术组，差异有统计学意义(P<0.001),并且治疗剂量增加，疗效增强。病理组织切片观察显示不同剂量的鹿茸多肽治疗后，组织水肿减轻，炎性细胞浸润减轻；尤以15 mg治疗组恢复最明显。
结论：鹿茸多肽具有促进脊髓损伤大鼠运动功能恢复的作用，且呈剂量依赖性。 |
| 【关键词】鹿茸多肽 脊髓损伤 细胞保护 |
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| Protective effect of velvet antler polypeptide(VAP)on rats with the spinal cord injury |
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ABSTRACT
Objective: To investigate the protective effect of antler polypeptide on the rats with spinal cord injury(SCI).
Methods: The model rats were treated with different doses of antler polypeptide,and its effect on motor function,ethology and pathological changes of spinal cord of the rats observed.
Results: Seven days after treatment with different doses of antler polypeptide,rat's motor activity was recovered in some extent. Significant difference(P<0.001)was found between the antler polypeptide treatment group and operation group. The effect could be enhanced by increase of the doses. We observerd the effect on the pathological change of spinal cord in rat,and found the tissue edema and inflammatory infiltration were relieved after treatment with different doses of antler polypeptide,especially in the dose of 15 mg antler polypeptide.
Conclusion: Antler polypeptide can promote the motor function recovery in SCI rats,and its action is dose-dependent. |
| KEY WORDS Antler polypeptide Spinal cord injuries Cytoprotection |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李振华,冷向阳,高忠礼.鹿茸多肽对脊髓损伤保护作用的实验研究[J].中国骨伤,2008,21(4):285~286 |
| 英文格式: | LI Zhen-hua,LENG Xiang-yang,GAO Zhong-li.Protective effect of velvet antler polypeptide(VAP)on rats with the spinal cord injury[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(4):285~286 |
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