| 载药磷酸钙骨水泥治疗慢性骨髓炎研究进展 |
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投稿时间：2007-03-18
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| 作者 | Author | 单位 | Address | E-Mail |
| 陈红卫 |
CHEN Hong-wei |
义乌市中心医院骨科，浙江 义乌 322000 |
Deparment of Orthopedics,Yiwu Central Hospital,Yiwu 322000,Zhejiang,China |
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| 黄洪斌 |
HUANG Hong-bin |
义乌市中心医院骨科，浙江 义乌 322000 |
Deparment of Orthopedics,Yiwu Central Hospital,Yiwu 322000,Zhejiang,China |
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| 赵钢生 |
ZHAO Gang-sheng |
义乌市中心医院骨科，浙江 义乌 322000 |
Deparment of Orthopedics,Yiwu Central Hospital,Yiwu 322000,Zhejiang,China |
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| 季向荣 |
JI Xiang-rong |
义乌市中心医院骨科，浙江 义乌 322000 |
Deparment of Orthopedics,Yiwu Central Hospital,Yiwu 322000,Zhejiang,China |
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| 期刊信息：《中国骨伤》2008年，第21卷，第1期，第79-81页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:义乌市科技攻关项目(编号：2006-G3-15) |
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| 中文摘要:抗生素缓释系统具有局部抗生素浓度高，全身毒副作用小，缓慢释放，持续时间长等优点，已逐渐成为治疗慢性骨髓炎的一种重要方法。载药磷酸钙骨水泥(CPC)具有药物载体和修复骨缺损的双重作用，且能诱导骨的生长并同步降解，是一种理想的安全可靠的抗生素缓释载体材料。在彻底病灶清除的基础上用载药CPC植入骨缺损处为治疗慢性骨髓炎的一种理想的行之有效的方法，具有操作简便、效果佳、住院时间短等优点。本文拟就载药磷酸钙骨水泥的生物特性、实验研究和临床应用等方面作一综述。 |
| 【关键词】载药磷酸钙骨水泥 慢性骨髓炎 抗生素 |
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| Treatment of chronic osteomyelitis with antibiotic -loaded calcium phosphate cement |
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| ABSTRACT The antibiotic delayed release system which has the characteristics of high local antibiotic concentration,few adverse effects,slow release and long duration,has became one of important methods of treating chronic osteomyelitis. Because of its double action as drug carrier and bone repair material which can induce bone growth and degrade synchronously,drug impregnated calcium phosphate cement(diCPC)is an ideal and safe antibiotic slow release carrier. After clearing focus thoroughly,defect implant with diCPC is an effective method,which has the virtues of convenient operation, good effects and short staying time etc. This paper aims to summarize the biological properties,experimental study and clinical application of diCPC. |
| KEY WORDS Antibiotic-loaded calcium phosphate cement Chronic osteomyelitis Antibiotic |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈红卫,黄洪斌,赵钢生,季向荣.载药磷酸钙骨水泥治疗慢性骨髓炎研究进展[J].中国骨伤,2008,21(1):79~81 |
| 英文格式: | CHEN Hong-wei,HUANG Hong-bin,ZHAO Gang-sheng,JI Xiang-rong.Treatment of chronic osteomyelitis with antibiotic -loaded calcium phosphate cement[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(1):79~81 |
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