| 藻酸盐敷料与mEGF联合应用对难愈性创面bFGF影响的随机对照试验 |
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投稿时间：2006-10-10
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| 作者 | Author | 单位 | Address | E-Mail |
| 毕擎 |
BI Qing |
浙江省人民医院骨科,浙江杭州310014 |
Department of Orthopaedics,the People's Hospital of Zhejiang Province,Hangzhou 310014,Zhejiang,China |
zhangqiong88@126.com |
| 夏冰 |
XIA Bing |
浙江省人民医院骨科,浙江杭州310014 |
Department of Orthopaedics,the People's Hospital of Zhejiang Province,Hangzhou 310014,Zhejiang,China |
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| 朱丹杰 |
ZHU Dan-jie |
浙江省人民医院骨科,浙江杭州310014 |
Department of Orthopaedics,the People's Hospital of Zhejiang Province,Hangzhou 310014,Zhejiang,China |
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| 许励 |
XU Li |
浙江省人民医院病理科 |
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| 邱斌松 |
QIU Bin-song |
浙江省人民医院骨科,浙江杭州310014 |
Department of Orthopaedics,the People's Hospital of Zhejiang Province,Hangzhou 310014,Zhejiang,China |
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| 徐文娟 |
XU Wen-juan |
浙江省人民医院病理科 |
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| 章水均 |
ZHANG Shui-jun |
浙江省人民医院骨科,浙江杭州310014 |
Department of Orthopaedics,the People's Hospital of Zhejiang Province,Hangzhou 310014,Zhejiang,China |
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| 洪剑飞 |
HONG Jian-fei |
浙江省人民医院骨科,浙江杭州310014 |
Department of Orthopaedics,the People's Hospital of Zhejiang Province,Hangzhou 310014,Zhejiang,China |
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| 期刊信息：《中国骨伤》2007年，第20卷，第10期，第659-662页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:浙江省医药卫生科学基金(2002A011) |
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中文摘要:
目的:探讨联合应用藻酸盐敷料(alginate dressing)与冻干鼠表皮生长因子(mouse epidermal growth fac-tor,mEGF)对难愈性创面碱性成纤维细胞生长因子(basic fibroblast grow thfactor,bFGF)表达的影响,评价其疗效。
方法:采用前瞻性、随机、对照设计方法,选择经常规换药抗炎治疗1个月创面仍未愈合的18例患者,年龄18～61岁,平均36.4岁;男12例,女6例;足部11例,小腿3例,手4例。随机分成3组:藻酸盐敷料与mEGF联合治疗组(A组)、mEGF治疗组(B组)、常规治疗组(C组),每组6例。治疗7、14、21、28d后评价其创面愈合指数,7d和14d时行活组织检查常规病理学观察,免疫组织化学SP法评定bFGF表达阳性细胞数目。
结果:A、B组创面愈合均明显,A组较B组突出(P<0.05)。病理学检查显示:A组创面修复细胞增殖明显,表皮增厚,上皮化活跃;B组虽也有类似改变,但不如A组显著。免疫组织化学SP染色显示:3组bFGF表达均有上调,但以A组最为显著(P<0.05)。
结论:藻酸盐敷料与mEGF联合应用治疗难愈性创面,能协同两者优势,较单用mEGF疗效更佳。 |
| 【关键词】藻酸盐 表皮生长因子 碱性成纤维细胞生长因子 创伤愈合 随机对照试验 |
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| Effects of alginate dressing and mouse epidermal growth factor combination therapy on expression of basic fibroblast growth factor in patients with refractory wound:a randomized controlled trial |
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ABSTRACT
Objective:To explore the influence of alginate dressing and mouse epidermal growth factor(mEGF) combination therapy on expression of basic fibroblast growth factor in patients with refractory wound and evaluate its clinical effect.
Methods:Eighteen patients of skin defects treated by change dressing for one month in this study.There were 12 males and 6 females aged from 18 to 61 years(mean 36.4 years).The wounds occurred at foot in 11,calf in 3 and the hand in 4.The patients were randomly divided into 3 groups(there were 6 cases in every group):alginate dressing and mEGF group(group A),mEGF group(group B) and control group(group C).Wound closure indexes were measured in 7,14,21,28 days.The samples were harvested in 7,14 days for pathologic examination and the positive staining cells of basic fibroblast growth factor(bFGF) were determined by SP immunohistochemical staining technique.
Results:Wound healing was promoted in group A and group B and the wound closure indexes was increased in group A(P<0.05).Pathological examination showed the epidermis was thicker in group A than that in group B.Treatment by the alginate dressing combined with the mEGF,angiogenesis was active and granulation was enhanced.The expression of the bFGF was shown in the fibroblasts,the blood capillaries and the basal layer of the epidermis in group A,B and C.There was significant difference between group A and group B(P<0.05),group B and group C(P<0.05).
Conclusion:Combination therapy of alginate dressing and mEGF have a better results than that with mEGF only in patients with refractory wound. |
| KEY WORDS Alginate Epidermal growth factor Basic fibroblast growth factor Wound healing Randomized controlled trials |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 毕擎,夏冰,朱丹杰,许励,邱斌松,徐文娟,章水均,洪剑飞.藻酸盐敷料与mEGF联合应用对难愈性创面bFGF影响的随机对照试验[J].中国骨伤,2007,20(10):659~662 |
| 英文格式: | BI Qing,XIA Bing,ZHU Dan-jie,XU Li,QIU Bin-song,XU Wen-juan,ZHANG Shui-jun,HONG Jian-fei.Effects of alginate dressing and mouse epidermal growth factor combination therapy on expression of basic fibroblast growth factor in patients with refractory wound:a randomized controlled trial[J].zhongguo gu shang / China J Orthop Trauma ,2007,20(10):659~662 |
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