| 抗氧自由基防治骨筋膜室综合征23例 |
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投稿时间：2005-05-18
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| 期刊信息：《中国骨伤》2006年，第19卷，第1期，第20-21页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:探讨氧自由基（OFR）清除剂防治骨筋膜室综合征（OCS）的临床疗效。
方法:对2001年3月-2004年12月收治的23例OCS患者应用下列OFR清除剂:①20%甘露醇注射液250ml,30min内静脉滴注;②复方丹参注射液20ml（或川芎嗪注射液160mg）、七叶皂苷钠20mg、维生素C注射液4.0g分别加入5%葡萄糖或生理盐水注射液250ml中静脉滴注,每分钟约60滴（4ml）。上述药物首次4h内滴完,用药后动态测定骨筋膜室压力。大于30mmHg时立即切开深筋膜减压,小于30mmHg（或切开减压术后）继续应用上述药物5~7d,每天1次。其中20%甘露醇根据肿胀程度调整为125~250ml,6h或8h1次。同时维持液体轻度负平衡状态及电解质平衡,预防感染,支持治疗。
结果:经6~24个月随访,23例应用OFR清除剂治疗后17例痊愈。因入院较晚,6例切开深筋膜减压后3例痊愈,3例伤残。总有效率86.9%。
结论:创伤早期应用OFR清除剂可以明显减轻四肢再灌注损伤,降低OCS的发生率及伤残率。 |
| 【关键词】骨筋膜室综合征 抗氧化剂 |
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| Assist treatment of 23 cases of osteofascial compartment syndrome with antioxidants |
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ABSTRACT
Objective:To explore the clinical effect of antioxidants for the prevention and cure of OCS(osteofascial compartment syndrome).
Methods:From May 2001 to December 2004,23 patients with OCS were treated with antioxidants:①Using 20% Mannitol 250 ml intravenous drip in 30 minutes.②Salvia Miltiorrhiza 20 ml(or ligastraxzini 160 mg),Sodium aescinate 20 mg and Vitamin C 4.0 g were respectively dissolved in 5% dextrose or saline 250 ml,which were injected by intravenous drip(60 drips per minute).The above-mentioned drugs were used in 4 h at first,then the muscular osteofascial compartment pressure was measured with dynamic method.If the pressure was more than 30 mmHg,fasciotomy was performed at once.These drugs were used 5-7 days(one time per day) when the pressure was less than 30 mmHg or after fasciotomy.20% Mannitol was used 125-250 ml according to swelling degree(one time per 6-8 h),keeping the negative fluid balance infection and electrolytes balance,preventing infection and holding out treatment.
Results:After treatment with OFR scavenger,all patients were followed up from 6 to 12 months.17 cases obtained excellent.6 cases with late hospitalization were treated with fasciotomy,of them,3 cases obtained excellent,3 cases disabled.The total effective rate was 86.9%.
Conclusion:In early injury,using OFR scavenger was effective to reduce the ischemia and reperfusion injury,decrease the incidence rate of OCS and invalidity rate. |
| KEY WORDS Osteofascial compartment syndrome(OCS) Antioxidants |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 付常国.抗氧自由基防治骨筋膜室综合征23例[J].中国骨伤,2006,19(1):20~21 |
| 英文格式: | FU Chang-guo.Assist treatment of 23 cases of osteofascial compartment syndrome with antioxidants[J].zhongguo gu shang / China J Orthop Trauma ,2006,19(1):20~21 |
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