| 雌激素与骨性关节炎 |
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摘要点击次数: 1937
全文下载次数: 1824
投稿时间：2005-07-01
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| 期刊信息：《中国骨伤》2005年，第18卷，第12期，第766-768页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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| 中文摘要:雌激素低于正常水平的绝经后妇女更易患骨性关节炎表明雌激素是骨性关节炎重要调节因子。已经证实正常和骨性关节炎关节软骨均存在雌激素受体(α受体和β受体),说明关节软骨是雌激素的靶组织。雌激素可以通过细胞因子和细胞生长因子等多种途径调节软骨细胞的功能,对雌激素影响软骨细胞代谢的可能机制也进行了动物实验研究。本文就雌激素在软骨细胞代谢中的作用和雌激素替代治疗进行综述。 |
| 【关键词】雌激素类 骨关节炎 综述文献 |
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| Estrogen and Osteoarthritist |
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| ABSTRACT In menopausal women whose estrogens level are lower than normal,the incidence rate of osteoarthristis(OA) is higher,suggesting that estrogens may be important regulator of OA.It is identified that estrogens receptors(receptor α and receptor β) exists in articular cartilage of normal persons as well as OA patients,indicating that articular cartilage is the targeted tissue of estrogens.Estrogens can regulate chondrocyte function with the help of cytokine and cellular growth factors.The possible mechanism of estrogens in the influence on metabolism of chondrocyte has been studied in animal experiments.This article reviewed the effects of estrogens on metabolism of chondrocyte and application of estrogens replacement therapy. |
| KEY WORDS Estrogens Osteoarthritis Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 任海龙,邢国胜,白人骁.雌激素与骨性关节炎[J].中国骨伤,2005,18(12):766~768 |
| 英文格式: | REN Hai-long,XING Guo-sheng,BAI Ren-xiao.Estrogen and Osteoarthritist[J].zhongguo gu shang / China J Orthop Trauma ,2005,18(12):766~768 |
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