| 股骨头坏死中医证型与相关理化指标关系的研究 |
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投稿时间：2005-03-02
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| 作者 | Author | 单位 | Address | E-Mail |
| 陈卫衡 |
CHEN Wei-heng |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
drchenwei2heng@163.com |
| 刘道兵 |
LIU Dao-bing |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
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| 孙凯 |
SUN Kai |
长春市第二医院 |
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| 孙钢 |
SUN Gang |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
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| 张洪美 |
ZHANG Hong-mei |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
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| 顾力军 |
GU Li-jun |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
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| 张磊 |
ZHANG Lei |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
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| 赵铁军 |
ZHAO Tie-jun |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Acad emy of TCM,Beijing 100700,China |
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| 期刊信息：《中国骨伤》2005年，第18卷，第9期，第513-516页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家自然科学基金资助(编号:30271565) |
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中文摘要:
目的:研究血浆脂蛋白及凝血异常在股骨头坏死中的变化规律,探讨其与股骨头坏死中医辨证各型的相关性。
方法:将94例股骨头坏死患者进行中医辨证分型,气滞血瘀型21例(A组)、痰瘀阻络型25例(B组)、经脉痹阻型24例(C组)及肝肾亏虚型24例(D组),同时检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白AI(apoAI)、载脂蛋白B(apoB)以及血小板计数(PLT)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)等指标,统计、分析中医证型与血浆脂蛋白及凝血指标的关系。
结果:组间比较发现,各中医证型组中血脂及凝血异常变化表现了一定的规律,在A组中,APTT最高,PT和FIB最低;在B组中,FIB最高,HDL-C、LDL-C及apoAI、apoB表现为最低;在C组中,TC、TG、LDL-C及apoB、PLT则表现最高;而D组以HDL-C、apoAI及PT表现最高,PLT及APTT最低。统计结果显示组间差异有显著性意义,P<0.05或0.01。
结论:血管内凝血与脂质代谢紊乱是股骨头坏死的病理基础,“痰瘀同治”应当成为治疗股骨头坏死的最基本的治则。 |
| 【关键词】股骨头坏死 病理学 分类法 中医学 |
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| Study on correlation between syndrome types of femoral head necrosis by TCM theory(中医证型) and related physicochemical indexes |
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ABSTRACT
Objective: To study changing regulation of the cont ent of lipoprotein in plasm and disturba nce of blood coagulation during the whol e processes of femoral head necrosis,so as to explore its correlation with syndr ome types of femoral head necrosis by TC M theory(中医证型).
Methods: Of 94 patients with femoral head ner osis,21 were stagnancy of qi and blood stasis type(气滞血瘀型)(Group A),25 stagnati on of phlegm and blood stasis in collate ral branch of the large channel type(痰瘀阻 络型)(Group B),24 numbness blockage of cha n nels type(经脉痹阻型)(Group C),and 24 deficie nc y of liver- yin and kidney- yin type(肝 肾亏虚型)(Group D).The physicochemical index e s,such as total cholesterol(TC),triglyce ride(TG),high density lipoprotein choles terol(HDL-C),low density lipoprotein-cho lesterol(LDL-C),apolipoprotein AI (apoAI ) and apo-lipoprotein B (apoB) were dete cted with the automatism b iochemical analysor of Olypas AU 400.Pla telet(PLT),prothrombin time (PT),activat ed partial thromboplastic time (APTT) an d fibrinogen (FIB) were determined with the automatism biochemical analysor of stago.SPSS 10.0 statistics software was used.
Results: The APTT value was higher and PT,FIB val ues lower in Group A than those in other groups.The FIB value was highest and HD L-D,LDL-C,apoAI,apoB values lowest in Gr oup B.In Group C,the values of TC,TG,LDL -C,apoB and PLT were highest.In Group D ,the HDL-C,apoAI and PT values were high est,but PLT and APTT values were lowest( P<0.05 or 0.01).
Conclusion: Intravascular coaguation and metabolic d isturbance of lipid are regareded as pat h ologic factors of femoral head necrosis ,so treating phlegm and blood stasis at the same time(痰瘀同治)should be basic treat ment rule of his disease. |
| KEY WORDS Femur head necrosis Pathology Classifi cation Medicine,Chinese traditional |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈卫衡,刘道兵,孙凯,孙钢,张洪美,顾力军,张磊,赵铁军.股骨头坏死中医证型与相关理化指标关系的研究[J].中国骨伤,2005,18(9):513~516 |
| 英文格式: | CHEN Wei-heng,LIU Dao-bing,SUN Kai,SUN Gang,ZHANG Hong-mei,GU Li-jun,ZHANG Lei,ZHAO Tie-jun.Study on correlation between syndrome types of femoral head necrosis by TCM theory(中医证型) and related physicochemical indexes[J].zhongguo gu shang / China J Orthop Trauma ,2005,18(9):513~516 |
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