| 骨生注射液对实验性骨性关节炎家兔血浆SOD和MDA的影响 |
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投稿时间：2003-01-13
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| 期刊信息：《中国骨伤》2004年，第17卷，第10期，第593-595页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:四川省教委资助课题(509) |
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中文摘要:
目的:探讨骨生注射液对骨性关节炎的治疗作用。
方法:用日本大耳白兔造成骨性关节炎模型并分组治疗,观察各组动物的组织学变化并将血浆超氧化物歧化酶(SOD)、丙二醛(MDA)作为观测指标。
结果:光镜下显示模型组胫骨侧软骨坏死脱落,骨质裸露,SOD下降,MDA上升。经骨生注射液治疗,可见蓝绿色胶原保留达1／2以上,血中SOD明显升高,MDA下降。
结论:骨生注射液能有效对抗关节炎软骨退变,增强机体清除自由基的能力,治疗骨性关节炎。 |
| 【关键词】骨性关节炎 超氧化物歧化酶 丙二醛 |
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| Experimental research of the effect of "Gusheng injection" on plasm SOD and MDA of osteoarthritic rabbies |
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ABSTRACT
Objective: To explore the effect of "Gusheng injection" (GSI) on the treatment of os-teoarthritic (OA).
Methods:OA experimental models were made in Japanese white rabbits. The rabbits were devided into different groups for different treatment. Histological changes of superoxide dismutase(SOD) and MDA were observed.
Results: In the model group, necrosis and exfoliation of tibial cartilage and exposed sub-chondral bone were observed with light microscope. SOD level decreased and MDA level increased in plasm. However,in the GSI group,more than 1/2 collagen were kept. SOD level obviously increased and MDA level decreased in plasm.
Conclusion:GSI can prevent degeneration of articular cartilage, improve the ability to clear free radical. There is reasonable effect for the treatment of OA. |
| KEY WORDS Osteoarthritis SOD MDA |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 江中潮,何洪阳,刘罡,邓友章,黄勇,刘毅,肖裕华.骨生注射液对实验性骨性关节炎家兔血浆SOD和MDA的影响[J].中国骨伤,2004,17(10):593~595 |
| 英文格式: | JIANG Zhong-chao,HE Hong-yang,LIU Gang,DENG You-zhang,HUANG Yong,LIU Yi,XIAO Yu-hua.Experimental research of the effect of "Gusheng injection" on plasm SOD and MDA of osteoarthritic rabbies[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(10):593~595 |
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