| 颈椎失稳所致心肌缺血家兔心肌超微结构的观察 |
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投稿时间：2003-03-04
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| 期刊信息：《中国骨伤》2004年，第17卷，第1期，第7-9页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:探讨颈椎错位失稳对缺血心肌超微结构改变的影响。
方法:通过手术切断C5～C6、C6～C7、C7～T1的棘间韧带,旋转错位C6和C7椎体,建立颈椎错位失稳模型。分别在术后1、2、3个月时采用透射电镜观察缺血心肌细胞超微结构的改变情况。
结果:术后1个月心肌细胞无明显改变,术后2、3个月时,心肌细胞的膜性细胞器出现了明显的病理损害,肌丝松散、线粒体肿胀,内嵴损害,糖原颗粒减少,这些表现随着时间的推移逐渐加重。
结论:颈椎长期失稳可引起缺血心肌出现器质性损害;颈椎病可能为冠心病的一个重要病因。 |
| 【关键词】颈椎病 心肌缺血 动物,实验 |
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| Observation on ultrastructure of ischemic myocardium in rabbits with cervical vertebral instability |
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ABSTRACT
Objective:To inquire into influence of cervical vertebral instability on the ultrastructure of ischemic myocardium.
Methods:Animal models were made by cutting off supraspinal ligaments of C5～C6, C6～C7, C6～T1,ratating and displacing C6～C7 vertebral bodies.The changes of ultrastructure of ischemic myocardium were observed with electrical microscope at 1,2,3 months after the operation.
Results:At 1 month after operation,no changes were found.But at 2,3 months after operation,pathologic changes of myocardial cell,such as areosis of myofilament,mitochondrial swelling,quantity of crista decreased,were found,which gradually aggravated along with time.
Conclusion:Long-term cervical vertebral instability could induce organic damage of ischemic myocardium.Cervical spondylosis may be an important factor of coronary heart disease. |
| KEY WORDS Cervical spondylosis Myocardial infarction Animals,laboratory |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 齐越峰,张军,孙树椿,付宝弛.颈椎失稳所致心肌缺血家兔心肌超微结构的观察[J].中国骨伤,2004,17(1):7~9 |
| 英文格式: | QI Yue-feng,ZHANG Jun,SUN Shu-chun,FU Bao-chi.Observation on ultrastructure of ischemic myocardium in rabbits with cervical vertebral instability[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(1):7~9 |
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