| 创伤患者凝血及血栓前状态实验诊断指标的变化 |
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投稿时间：2002-08-09
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| 作者 | Author | 单位 | Address | E-Mail |
| 王毅 |
WANG Yi |
天津医院,天津 300211 |
The Hospital of Tianjin, Tianjin 300211 |
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| 邓桂芳 |
DENG Guifang |
天津医院,天津 300211 |
The Hospital of Tianjin, Tianjin 300211 |
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| 吴玉芳 |
WU Yufang |
天津医院,天津 300211 |
The Hospital of Tianjin, Tianjin 300211 |
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| 王淑云 |
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天津医院,天津 300211 |
The Hospital of Tianjin, Tianjin 300211 |
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| 刘长明 |
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天津医院,天津 300211 |
The Hospital of Tianjin, Tianjin 300211 |
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| 期刊信息：《中国骨伤》2003年，第16卷，第4期，第202-205页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:探讨血栓形成前血管内皮细胞、血小板、凝血、抗凝、纤溶系统等多种因素改变的综合作用,寻找特异、敏感的指标识别血栓前状态。
方法:将创伤骨折患者40例,DVT患者10例及40例正常人血浆标本按对照、创伤手术后、DVT及同一组患者手术前后进行分组,用放免、酶免及ACL血凝仪分别测定血浆α-颗粒膜蛋白（GMP-140）、血栓烷（TXB2）、6-酮-前列腺素1α、凝血酶时间（PT）、部分活化凝血酶元时间（APTT）、纤维蛋白元（FIB）、D-二聚体（D-D）等指标。
结果 :创伤组、DVT组与对照组比较GMP-140、TXB2、FIB、D-二聚体有显著增高,6-Keto-PGF1α有显著下降;APTT、PT的变化不明显。创伤后同一组患者手术前后比较,GMP-140、TXB2、D-二聚体三项指标差异有显著性（P<0.05）。其它几项指标手术前后无显著性差异。GMP-140、TXB2、D-二聚体三项指标对不同骨折患者检测阳性率差异无显著性。 |
| 【关键词】创伤 静脉血栓形成 实验室诊断 |
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| Chang of thrombosis index and diadynamic criteria of prethrombotic state in trauma patients |
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ABSTRACT
Objective:To evaluate the clinical significance of human plasma GMP-140,TXB2,6-Keto-PGF1a ,PT,APTT,FUKD-Dimer level for the diagnosis of prethrombotic state in trauma patient
Methods:90 cases were divided into normal control group, trauma post-operative group and DVT group. Plasma GMP-140, TXB2,-Keto-PGF1a.PT.APTT.FIB,D-Dimer level were measured by RIA.ELISA and ACL-200.
Results:Compared with the control group, GMP-140,TXB2 ., FIB, D-Dimer leve were significantly higher, 6-Keto-PGF1a were significantly lower in the post-operative and DVT group, while APTT and PT did not changes obviously in all groups. Comparison between preoperative and postoperative of the trauma patients showed significant different in GMP-140,TXB2,D-Dimer leve (P<0.05),not for others index.The positive rate of examining GMP-140,TXB2,ND-Dimer in trauma patients did not show difference.
Conclusion:Thrombocyte activation and endothelial cell injury may be cause by trauma, the measurement of this index is valuable for the diagnosis and prevention of prethrombotic state. |
| KEY WORDS Trauma Venous thrombosis Labratory diagnosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 王毅,邓桂芳,吴玉芳,王淑云,刘长明.创伤患者凝血及血栓前状态实验诊断指标的变化[J].中国骨伤,2003,16(4):202~205 |
| 英文格式: | WANG Yi,DENG Guifang,WU Yufang.Chang of thrombosis index and diadynamic criteria of prethrombotic state in trauma patients[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(4):202~205 |
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