| 中西医结合治疗激素性股骨头坏死的实验研究 |
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投稿时间：2002-09-13
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| 作者 | Author | 单位 | Address | E-Mail |
| 李峻辉 |
LI Junhui |
成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 宁亚功 |
NING Yagong |
成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 彭仲杰 |
PENG Zhongjie |
成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 栾晓文 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 叶建红 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 张晓云 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 贺斌 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 王云华 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 吴亚玲 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 江建国 |
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成都军区昆明总医院全军中医中心,云南昆明650032 |
Kunming General Hospital of Chengdu Military Yunnan Kunming 650032 |
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| 期刊信息：《中国骨伤》2003年，第16卷，第3期，第145-147页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:全军医药卫生科研基金资助项目(01MA045) |
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中文摘要:
目的:探讨中西医结合治疗激素性股骨头坏死的作用机制。
方法:将40只兔子随机分为对照组、模型组、中药组、介入组和综合组。于治疗后8周,分别进行血液流变学、血脂、股骨头空骨陷窝数测定及观察。
结果中药组和介入组动物血浆和全血粘度、红细胞聚集指数、总胆固醇、甘油三脂和股骨头空骨陷窝率均明显低于模型组(P<0.05)。综合组与模型组比较,全血高、中切粘度、红细胞聚集指数和甘油三脂明显降低,有显著差异(P<0.01),与中药组和介入组比较亦有差异(P<0.05),全血低切粘度、血浆粘度、总胆固醇降低,与模型组比较仍有差异(P<0.05),空骨陷窝率较模型组显著降低(P<0.01)。
结论:中药组、介入组和综合组治疗股骨头缺血性坏死,均可以降低血脂,改善血液循环,促进坏死骨修复和新生骨再生,其中综合组疗效优于单纯内服中药组及单纯介入治疗组。 |
| 【关键词】股骨头坏死 中西医结合疗法 血液流变学 病理学 |
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| Experimental study on the femoral head necrosis treated by therapy of western medicine combined with traditional Chinese medicine |
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ABSTRACT
Objective:To study the mechanism of western medicine combined with TCM for treatment of the femoral head necrosis induced by cortisone
Methods:40 rabbits were divided into control,model Chinese herb group,intervention group and combined group.The hemorrheology,serum lipid and the number of empty lacuna in the femoral head were observed on the rabbits treated in 8 weeks.
Results:The level of plasma viscosity,blood viscosity,RBC aggregation index,total cholesterol,trilyceride and the number of the empty lacuna in the herb and intervention group were lower than those in the model group (P<0.05).The level of blood viscosity,RBC aggregation index and trilyceride in combined group were lower than those in the model group (P<0.01) and also different in the herb and intervention group (P<0.05).The level of plasma viscosity,blood viscosity,RBC aggregation index and total cholesterol were lower (P<0 05) and the number of femoral head empty lacuna was also lower than that of model (P<0.01).
Conclusion:Herb,intervention or combined therapy can reduce serum lipid,improve blood circulation,make the active ostogenesis taking place and repair the femoral head avascular necrosis.The therapeutic effect of combined group was better than that of herb or intervention group. |
| KEY WORDS Femur head necrosis TCM WM therapy Hemorheology Pathology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 李峻辉,宁亚功,彭仲杰,栾晓文,叶建红,张晓云,贺斌,王云华,吴亚玲,江建国.中西医结合治疗激素性股骨头坏死的实验研究[J].中国骨伤,2003,16(3):145~147 |
| 英文格式: | LI Junhui,NING Yagong,PENG Zhongjie.Experimental study on the femoral head necrosis treated by therapy of western medicine combined with traditional Chinese medicine[J].zhongguo gu shang / China J Orthop Trauma ,2003,16(3):145~147 |
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