| 几丁质-硅胶复合膜引导性骨再生的实验研究 |
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投稿时间：2000-04-24 修订日期：2000-09-04
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| 作者 | Author | 单位 | Address | E-Mail |
| 陈锦平 |
CHEN Jin ping |
浙江省人民医院,浙江杭州310014 |
The People's Hospital of Zhejiang Province,Zhejiang Hangzhou,310014 |
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| 张帆 |
ZHANG Fan |
浙江省人民医院,浙江杭州310014 |
The People's Hospital of Zhejiang Province,Zhejiang Hangzhou,310014 |
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| 赵仲生 |
ZHAO Zhong sheng |
浙江省人民医院,浙江杭州310014 |
The People's Hospital of Zhejiang Province,Zhejiang Hangzhou,310014 |
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| 潘晓华 |
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浙江省人民医院,浙江杭州310014 |
The People's Hospital of Zhejiang Province,Zhejiang Hangzhou,310014 |
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| 王官将 |
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上海第二军医大学,上海 |
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| 曹梅迅 |
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上海昆虫研究所,上海 |
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| 徐文娟 |
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浙江省人民医院,浙江杭州310014 |
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| 期刊信息：《中国骨伤》2001年，第14卷，第7期，第405-407页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:非教育系统留学回国人员科研基金资助 |
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中文摘要:
目的：通过对GBR连续组织学研究及放射学检查,探讨几丁质硅胶复合膜在引导性骨再生(guidedboneregenerationGBR)中的作用。
方法：取新西兰兔24只,造成双侧桡骨15mm骨缺损,将48只肢体平均分为A、B、C、D组,每组各12只肢体,分别用几丁质硅胶复合膜、几丁质膜、硅胶管及空白对照。于手术后2、4、6、8、12、16周处死每组各两只兔,标本行X线及组织学检查。
结果：几丁质硅胶复合膜组的骨缺损区在成骨活动的活跃程度、骨再生量和再生髓腔结构等方面均优于单纯几丁质、硅胶管及空白对照组(P<005),使骨缺损得到了修复。
结论：几丁质硅胶复合膜能促进内、外骨痂的生长。 |
| 【关键词】引导组织再生 骨痂 组织学,比较 |
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| Experimental study of guided bone regeneration with chitin silica gel complex pellicle |
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ABSTRACT
Objective:To explore the role of chitin silica gel complex pellicle in the process of guided bone regeneration(GBR) by using continuous histological study and radiological examination
Methods:Bone defects of 15mm on bilateral radius were created in 14 New Zealand rabbits.The 48 limbs were equally divided into 4 groups:A.chitin silica gel complex pellicle group;B.chitin pellicle;C.silica tube and D.control group.Two rabbits in each group were sacrificed at 2nd,4th,6th,8th,12th and 16th weeks after operation and the samples procured at the fracture sites were used for X ray and histological examinations.
Results: The osteoblastic activity,quantity of regenerative bones and regenerative marrow cavity structure in the bone defect region of group A were much better than those of group B,C and D( P<0 05 ).The bone defect was repaired well in group A.
Conclusion:Chitin silica gel complex pellicle might be able to promote growth of interior and external callus. |
| KEY WORDS Guided tissue regeneration Callus Histology comparative |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陈锦平,张帆,赵仲生,潘晓华,王官将,曹梅迅,徐文娟.几丁质-硅胶复合膜引导性骨再生的实验研究[J].中国骨伤,2001,14(7):405~407 |
| 英文格式: | CHEN Jin ping,ZHANG Fan,ZHAO Zhong sheng.Experimental study of guided bone regeneration with chitin silica gel complex pellicle[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(7):405~407 |
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