| ICAM-1和VCAM-1在创伤骨折及手术过程中的测定 |
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投稿时间：2000-02-25 修订日期：2000-06-28
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| 作者 | Author | 单位 | Address | E-Mail |
| 颉玉欣 |
XIE Yu xin |
河北医科大学第三医院,河北石家庄050051 |
The Third Affiliated Hospital of Hebei Medicine University,Hebei Shijiazhuang,050051 |
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| 赵驻军 |
ZHAO Zhu jun |
河北医科大学第三医院,河北石家庄050051 |
The Third Affiliated Hospital of Hebei Medicine University,Hebei Shijiazhuang,050051 |
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| 汤惠华 |
TANG Hui hua |
河北医科大学第三医院,河北石家庄050051 |
The Third Affiliated Hospital of Hebei Medicine University,Hebei Shijiazhuang,050051 |
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| 李继云 |
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河北医科大学第三医院,河北石家庄050051 |
The Third Affiliated Hospital of Hebei Medicine University,Hebei Shijiazhuang,050051 |
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| 邸军 |
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河北医科大学第三医院,河北石家庄050051 |
The Third Affiliated Hospital of Hebei Medicine University,Hebei Shijiazhuang,050051 |
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| 丁俊琴 |
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河北医科大学第三医院,河北石家庄050051 |
The Third Affiliated Hospital of Hebei Medicine University,Hebei Shijiazhuang,050051 |
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| 期刊信息：《中国骨伤》2001年，第14卷，第7期，第403-404页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：探讨创伤骨折及手术过程中细胞间粘附分子1(ICAM1)和血管细胞粘附分子1(VCAM1)的含量变化,了解创伤骨折手术后是否感染以及与创伤程度的相关性。
方法：采用ELISA酶联免疫吸附法对50例患者在创伤骨折及手术前后ICAM1和VCAM1的含量进行测定。以创伤时间进行分组,其中,创伤骨折后90分钟内进行手术的患者21例;骨折后1～3天手术的患者29例;正常对照组30例。
结果：创伤骨折后90分钟进行手术的21例患者血清ICAM1和VCAM1的含量与正常对照组的含量相比无显着性差异。而创伤骨折后1～3天手术的患者,检测ICAM1和VCAM1的含量明显高于正常对照组和手术前的含量,有显着性差异。创伤骨折及手术后发生继发感染的12例患者的ICAM1和VCAM1的含量明显高于手术后未发生感染组的含量,有显着性差异。
结论：创伤骨折及手术能使机体的各种机能发生改变,淋巴细胞和巨噬细胞释放一些细胞因子,并可使内皮细胞和成纤维细胞表达ICAM1和VCAM1的功能增强。 |
| 【关键词】细胞粘附分子 骨折 创伤和损伤 |
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| Determinations the contents of ICAM-1 and VCAM-1 in the patients with traumatic fracture and during the course of operation |
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ABSTRACT
Objective:To determine the contents of ICAM 1 and VCAM 1 in patients with traumatic fracture and during the course of operation,in order to detect if infection occurred after operation and its relationship with the local conditions of the wound
Methods:The contents of ICAM 1 and VCAM 1 in 50 patients suffered from fracture and underwent operation were detected by using Enzyme linked immunoadsordent assay(ELISA).The patients were divided according to the time of injury:group 1 of 21 cases had surgery within 90 minutes after fracture,and group 2 of 29 within 1～3 days.Group 3 of 30 normal persons served as control group.
Results: The contents of ICAM 1 and VCAM 1 in group 1 had no obvious difference from that of control group.While the contents of ICAM 1 and VCAM 1 in group 2 were higher than that of control group and before operation.The contents of ICAM 1 and VCAM 1 in 12 cases in which infection occurred after fracture and operation were much higher than that in patients with infection.
Conclusion:Trauma fracture and operation can cause release of cytokine by lymphocyte and macrophage,high expression of ICAM 1 and VCAM 1 by endodermis cells and fibroblast.After trauma and operation,when secondary infection occurred,the migration of white blood cell(WBC) is especially depended on participation of ICAM 1 and VCAM 1. |
| KEY WORDS Cell adhesion molecules Fracture Trauma and injury |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 颉玉欣,赵驻军,汤惠华,李继云,邸军,丁俊琴.ICAM-1和VCAM-1在创伤骨折及手术过程中的测定[J].中国骨伤,2001,14(7):403~404 |
| 英文格式: | XIE Yu xin,ZHAO Zhu jun,TANG Hui hua.Determinations the contents of ICAM-1 and VCAM-1 in the patients with traumatic fracture and during the course of operation[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(7):403~404 |
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