| 股骨头缺血坏死发病机理的实验研究 |
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投稿时间：1999-09-30 修订日期：2000-03-27
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| 作者 | Author | 单位 | Address | E-Mail |
| 林乔龄 |
Qiaoling |
漳州市中医院,福建漳州363000 |
Zhangzhou Hospi tal of TCM,Fujian Zhangzhou,363000 |
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| 张嵩图 |
ZHANG Song tu |
漳州市中医院,福建漳州363000 |
Zhangzhou Hospi tal of TCM,Fujian Zhangzhou,363000 |
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| 陈联源 |
CHEN Lianyuan |
漳州市中医院,福建漳州363000 |
Zhangzhou Hospi tal of TCM,Fujian Zhangzhou,363000 |
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| 王建云 |
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漳州市中医院,福建漳州363000 |
Zhangzhou Hospi tal of TCM,Fujian Zhangzhou,363000 |
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| 期刊信息：《中国骨伤》2001年，第14卷，第3期，第150-151页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:福建省中医药科研课题(编号;9705) |
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中文摘要:
目的;探讨股骨头坏死的发病机理,为正确指导临床治疗、防治股骨头缺血坏死提供一个可靠依据。
方法;20只新西兰大白兔随机分为两组;模型组和空白对照组。向模型组动物腹腔内注射醋酸氢化泼尼松,造成股骨头缺血性坏死模型。在第8次注射激素后第4天模型Ⅰ组和对照Ⅰ组各取5只动物进行取材实验,于注射激素后第30天模型Ⅱ组和对照Ⅱ组各取5只进行同上实验。观察模型组和对照组的一般情况、股骨头外观、股骨头结构,测定骨密度。
结果;模型组动物较对照组股骨头骨质疏松,易于剖开凿切,镜下空骨陷窝数增多,脂肪细胞增多,骨小梁变细、稀疏中断,骨密度明显减低。
结论;认为股骨头缺血坏死发病期间经历了一个共同的病理过程,即骨质疏松期。 |
| 【关键词】股骨头坏死 病理过程 骨质疏松 |
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| An experimental study of pathoge nesis of ischemic necrosis of femoral he ad |
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ABSTRACT
Objective;To explore the pathogenesis of ischemic necrosis of femoral head(INFH)in order t o search for an effective method for pre vention and treatment of INFH.
Methods;20 New Zealand rabbits were divided rand omly into two groups of the models and t h e controls.INFH models were produced by injecting hydroprednisone acetate q.d.in to the abdominal cavity of rabbits.10 ra bbits,which included 5 rabbits of model Ⅰ group and 5 of control Ⅰ group,were sa crificed at 4th day after injecting horm one for 8 days.Other 10 rabbits,which in cluded 5 rabbits of model Ⅱ group and 5 of control Ⅱ group,were sacrificed at th e 30th day after finishing injecting hor mone.The general conditions of the anima l,the outlook and structure of femoral h ead of the rabbits were observed and bon e density was determined.
Results;Compared with control group,the rabbits of model group exhibited many changes;su ch as osteoporosis of femoral head which was easier to be cut,the presence of mo re bone lacuna and fat cell,the rarely s een and broken thinner trabeculae and a lower bone density.
Conclusion;There is a common pathological stage dur ing the course of pathogenesis of INFH,i .e.the stage of osteoporosis. |
| KEY WORDS Femoral? head necrosisPathologic |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 林乔龄,张嵩图,陈联源,王建云.股骨头缺血坏死发病机理的实验研究[J].中国骨伤,2001,14(3):150~151 |
| 英文格式: | Qiaoling,ZHANG Song tu,CHEN Lianyuan.An experimental study of pathoge nesis of ischemic necrosis of femoral he ad[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(3):150~151 |
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