| TNF-α、HA和LN对股骨头缺血性坏死致病作用的研究 |
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投稿时间：1997-10-10 修订日期：1998-03-23
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| 作者 | Author | 单位 | Address | E-Mail |
| 罗南萍 |
LUO Nan ping |
济南军区总医院,山东济南250031 |
The General Hospital of Jinan Military Area Shandong Jinan,250031 |
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| 杨道理 |
YANG Dao li |
济南军区总医院,山东济南250031 |
The General Hospital of Jinan Military Area Shandong Jinan,250031 |
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| 付志厚 |
FU Zhi hou |
济南军区总医院,山东济南250031 |
The General Hospital of Jinan Military Area Shandong Jinan,250031 |
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| 孙文杰 |
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济南军区总医院,山东济南250031 |
The General Hospital of Jinan Military Area Shandong Jinan,250031 |
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| 陈世敏 |
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济南军区总医院,山东济南250031 |
The General Hospital of Jinan Military Area Shandong Jinan,250031 |
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| 期刊信息：《中国骨伤》2000年，第13卷，第4期，第204-206页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：探讨细胞因子与细胞外间质成份在缺血性股骨头坏死(INFH）疾病发病中的作用。
方法：采用放射免疫分析法(RIA）对45例INFH患者进行血清肿瘤坏死因子(TNF-α）、透明质酸(HA）及层粘连蛋白(LN）的含量检测,并以30例健康人作为对照。
结果：INFH患者血清TNF-α、HA和LN含量均处于高水平状态,与对照组比较均具显着性差异(P<001）.不同病因组其TNF-α、HA和LN含量均有不同程度的改变。且TNF-α含量的增高与HA呈明显正相关(r=045,Ρ<005),与LN之间无相关性。
结论：TNF-α、HA和LN之间具有相互协同作用,并共同参与了INFH疾病发生发展的免疫病理过程。 |
| 【关键词】放射免疫分析法 股骨头坏死 病理过程 |
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| The Pathogenic Effect of TNF-α,HA and LN on Ischemic Necrosis of The Femoral Head |
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ABSTRACT
Objective:To study the relation between cellular factor,intercelluar substance and pathogenesis of ischemic necrosis of femoral head (INFH)
Methods:Tumor Necrosis Factor(TNF),Hyaluronic(HA)and Laminin(LN) in 45 patients with INFH were measured by radioimmunity analysis(RIA) 30 normal persons served as control
Results:TNF,HA and LN in patients with INFH were in higher levels than that in control group (Ρ<0 01);variations were seen in different causal groups Meanwhile,the increment of TNF correlated well with HA(r=0 45,Ρ<0 05),but had no correlation with LN
Conclusion s:TNF,HA and LN have cooperation in immunopathologic process of occurrence and development of INFH disease |
| KEY WORDS radioimmunity analysis Femur head necrosis Pathologic processes |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 罗南萍,杨道理,付志厚,孙文杰,陈世敏.TNF-α、HA和LN对股骨头缺血性坏死致病作用的研究[J].中国骨伤,2000,13(4):204~206 |
| 英文格式: | LUO Nan ping,YANG Dao li,FU Zhi hou.The Pathogenic Effect of TNF-α,HA and LN on Ischemic Necrosis of The Femoral Head[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(4):204~206 |
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