| 骨疏康对卵巢切除大鼠骨质量及基因表达的影响 |
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投稿时间：1999-04-01 修订日期：1999-08-07
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| 期刊信息：《中国骨伤》2000年，第13卷，第3期，第141-143页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家科委九五攻关资助课题(项目编号:96-906-05-04) |
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中文摘要:
目的:为进一步探讨骨疏康防治骨质疏松的作用机理。
方法:将27只3月龄Wistar雌性大鼠随机分为三组:假手术组(Sham)、卵巢切除组(OVX)、骨疏康组(GSK).给药后12周同时处死。取大鼠血、尿检测骨代谢生化指标,取股骨或腰椎测量骨密度、骨形态计量学参数、骨生物力学参数,取股骨和胫骨,测定骨粘连蛋白(ON)mRNA表达。
结果:与OVX组相比,GSK组股骨及L4骨密度明显增高,生物力学参数也有增加。GSK有抑制骨吸收作用。
结论:GSK增加骨量和骨强度的作用。 |
| 【关键词】去卵巢 生物力学 骨形态计量学 中草药 骨质疏松 |
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| Eeffect of Gushukang on bone quality and gene expression of osteonectin in ovariectomized rats. |
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ABSTRACT
Objective:To investigate the mechanisms of prevention and treatment of Gushukang on osteoporosis.
Methods:Ovariectomized(OVX)female Wistar rats(3 months old)were divided into three groups randomly:sham group.OVX group and GSK group.Biochemical markers,bone mineral density(BMD),bone histomorphometry,bone biomechanical properties and the expression of osteonectin(ON)mRNA of femur and tibia were measured at the end of the experiment.
Results:Compared with OVX rats,GSK significantly increased BMD of femur and L 4,also increased the mechanical properties of OVX rats.GSK inhibited bone resorption.
Conclusion:GSK increased bone mass and bone strength. |
| KEY WORDS Ovariectomized Biomechanics Bone histomorphometry Chinese herbal drugs Osteoporosis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 薛延,包方,李东,刚丕寰,蒋淑媛,黄公怡.骨疏康对卵巢切除大鼠骨质量及基因表达的影响[J].中国骨伤,2000,13(3):141~143 |
| 英文格式: | XUE Yan,BAO Fang,LI Dong.Eeffect of Gushukang on bone quality and gene expression of osteonectin in ovariectomized rats.[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(3):141~143 |
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