| 脊髓损伤后自由基变化及丹参对自由基影响的实验研究 |
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投稿时间：1998-04-01 修订日期：1998-09-19
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| 期刊信息：《中国骨伤》1999年，第12卷，第5期，第16-18页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:了解实验性脊髓损伤后血液和脊髓组织中自由基的变化及丹参对自由基的清除作用。
方法:选用家兔35只,分为正常组、损伤组、生理盐水对照组、丹参治疗组A和B等5组,后4组按Allen氏法致伤造成脊髓损伤模型,后3组术后分别立即静脉注射生理盐水,不同浓度丹参注射液。2小时后取血液和脊髓组织测丙二醛(MDA)和超氧化物歧化酶(SOD),并观察脊髓病理变化。
结果:脊髓损伤后血液和脊髓组织中MDA升高,SOD下降,使用丹参后可使MDA降低,SOD升高。
结论:脊髓损伤后血液和脊髓组织中自由基含量升高,丹参能够有效清除自由基,两个丹参治疗组之间的抗自由基作用无显著性差异。 |
| 【关键词】实验性脊髓损伤 自由基 丹参 |
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| Experimental Study on Free Radical Change after Spinal Cord Injury and the Effect of Salvia Miltiorrhiza on Free Radical |
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ABSTRACT
Objective:To study the changes of free radical in blood and spinal cord after spinal cord injury (SCI)and the elimination of free radical with Salvia Miltiorrhiza.
Methods: Thirty five rabbits were divided into five groups:normal group without SCI and treatment,injuried group applied SCJ only,normal saline group injected normal saline immediately after SCI,Salvia Miltiorrhiza A and B groups injected Salvia Miltiorrhiza in low and high dosage,respectively,immediately after SCJ.Two hours later,samples of blood and spinal cord were taken out to assay the contents of MDA and SOD and to examine the pathological changes of spinal cord.
Results: After SCI,MDA was increased and SOD was decreased in both blood and spinal cord.After injecting Salvia Miltiorrhiza,MDA was decreased and SOD was increased in both blood and spinal cord.
Conclusion: Free radicals in blood and spinal cord were increased after SCI.and free radicals can be eliminated efficiently with Salvia Miltiorrhiza.There was no significant difference in elimination of free radicals between two Salvia Miltiorrhiza treatment groups. |
| KEY WORDS Experimental spinal cord injury Free radical Salvia Miltiorrhiza |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 许翔,江曙.脊髓损伤后自由基变化及丹参对自由基影响的实验研究[J].中国骨伤,1999,12(5):16~18 |
| 英文格式: | Xu Xiang,Jiang Shu.Experimental Study on Free Radical Change after Spinal Cord Injury and the Effect of Salvia Miltiorrhiza on Free Radical[J].zhongguo gu shang / China J Orthop Trauma ,1999,12(5):16~18 |
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