| 黔岭藿合剂对大鼠去势后骨质疏松症的作用 |
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投稿时间：1996-08-19 修订日期：1996-12-04
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| 期刊信息：《中国骨伤》1997年，第10卷，第6期，第9-12页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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| 中文摘要:黔岭藿合剂是一个治疗骨质疏松症的复方。雌性大鼠去势后3个月建立绝经后高转型骨质疏松症模型,分为模型组、中药组、尼尔雌醇组。治疗3个月后,中药组、尼尔雌醇级较模型组空腹尿钙(U一Ca)/尿肌酐(U—Cr)、尿羟脯氨酸(U－HOP)/尿肌肝(U－Cr)比值均明显降低(P＜0.05,P＜0.01)；血清雌二醇(E2)、骨矿含量(BMC)和骨密度(BMD)均升高；而中药组血清骨钙素(BGP)高于尼尔雌醇组、模型组(P＜0.05)；尼尔雌醇组血清碱性磷酸酶(S－AKP)均低于中药组、模型组(均为P＜0.05)。结果表明黔岭藿合剂能改善骨质疏松大鼠的骨丢失状态,起到保护骨骼作用。 |
| 【关键词】骨质疏松症 黔岭藿合剂 大鼠 卵巢切除 |
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| Effects of Qianlinghuo Heji on Osteoporosis Induced by Ovariectomy:An Experimental Study |
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| ABSTRACT Qianlinghuo Heji(Epemedium Leptorrhizum Agent)is a mixture of Chinese medical herbs on osteoporosis.The rats'models of postmenopausal high
turnover osteoporosis were established three months after ovariectomy, and then divided into three groups;the Chinese drug group, nilestriol group, and model group. After treating for three months, the results showed that the ration of fasting urine calcium/urine creatinin and urine hydroxyproline/urine creatinin in Chinese druy group and in nilestriol group are obviously decreased than that in model group (P<0.05 and < 0.01,respectively);the serum estradiol, bone mineral capacity and bone mineral density in both the Chinese drug and nilestriol groups are increased than that in model group; the level of serum bone gal protein in Chinese drug group is higher than that in nilestriol and model groups (P < 0.05 );and the activity of serum alkaline phosphatase in nilestriol group is lower than that in Chinese drug and model groups (P<0.05). The results indicated that Qianlinghuo Heji can prevent the rats with osteoporosis from losing bone material and thus protect the bone. |
| KEY WORDS Ossteoporosis Chinese drug Qianlinghuo Heji Rat Ovariectomy |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陶有略,方亮,章志安,张文光,叶大付,郑德柱.黔岭藿合剂对大鼠去势后骨质疏松症的作用[J].中国骨伤,1997,10(6):9~12 |
| 英文格式: | Tao Youlue,Fang Liang,Zhang Zhian.Effects of Qianlinghuo Heji on Osteoporosis Induced by Ovariectomy:An Experimental Study[J].zhongguo gu shang / China J Orthop Trauma ,1997,10(6):9~12 |
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